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Normal urinary calcium/creatinine ratios in Turkish children

Omer Ceran1, Mehmet Akin, Zekeriya Aktürk

  • 1Department of Pediatrics, Haydarpasa Numune Training and Research Hosptial Uskudar, Istanbul, Turkey.

Indian Pediatrics
|October 8, 2003
PubMed

Insights

Establishing normal random urine calcium/creatinine ratio (UCa/Cr) values in Turkish children is crucial. This study found UCa/Cr decreases with age, providing age-specific reference ranges for pediatric hypercalciuria screening.

Area of Science:

  • Pediatric Nephrology
  • Clinical Chemistry
  • Biochemistry

Background:

  • The random urine calcium/creatinine ratio (UCa/Cr) is a valuable tool for screening hypercalciuria.
  • Established pediatric reference values for UCa/Cr vary globally and are lacking for Turkish children.

Purpose of the Study:

  • To determine age-specific normal reference values for random UCa/Cr in healthy Turkish children.
  • To investigate the relationship between UCa/Cr and age in the pediatric population.

Main Methods:

  • A cross-sectional study involving 324 healthy children aged 7 months to 14 years in Istanbul.
  • Random urine samples were analyzed for calcium and creatinine levels.
  • Children were stratified into four age groups for analysis.

Main Results:

  • Median UCa/Cr values were 0.19, 0.20, 0.14, and 0.10 for the respective age groups (<7 months, 8-18 months, 19 months-6 years, 7-14 years).
  • A significant inverse correlation was observed between UCa/Cr and age.
  • Age-specific 95th percentiles ranged from 0.24 to 0.76.

Conclusions:

  • This study establishes the first age-dependent normal reference values for random UCa/Cr in Turkish children.
  • Age and geographic location are important factors for interpreting UCa/Cr ratios in pediatric hypercalciuria screening.

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