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Trends in organ preservation.

Andrew James McLaren1, Peter John Friend

  • 1Nuffield Department of Surgery, John Radclffe Hospital, Oxford, UK.

Transplant International : Official Journal of the European Society for Organ Transplantation
|October 8, 2003
PubMed
Summary
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Urological Nephrectomies for Benign Disease: A Possible Missed Resource in Organ Donation.

Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantationยท2018
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Improving organ preservation is crucial due to donor shortages. Advances focus on solution additives, machine perfusion, and normothermic techniques to minimize graft injury and enhance transplant success.

Area of Science:

  • Transplantation science
  • Organ preservation technology

Background:

  • Static cold storage is the standard for organ preservation, aiming to maintain cellular ATP levels and minimize injury.
  • Expanding donor criteria and organ shortages necessitate improved preservation methods to reduce graft injury.

Purpose of the Study:

  • To review current and future advances in organ preservation technology.
  • To highlight strategies for minimizing ischemic injury and enhancing graft viability.

Main Methods:

  • Review of current organ preservation methods, including static cold storage.
  • Exploration of novel preservation strategies: additives to solutions, perfluorocarbons, organ modulation (biochemical/genetic), and machine perfusion.
  • Discussion of normothermic perfusion as an alternative preservation method.

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Main Results:

  • Static cold storage is limited, especially for marginal organs, and does not allow viability assessment.
  • Additives to preservation solutions, two-layer methods, organ modulation, and preconditioning show promise in minimizing ischemic injury.
  • Normothermic perfusion presents a potential alternative to cold storage for organ preservation.

Conclusions:

  • Current cold storage methods are insufficient for marginal organs and provoke ischemic injury.
  • Emerging strategies like solution additives, advanced perfusion techniques, and organ modulation offer improved organ preservation.
  • Normothermic perfusion warrants further investigation as a superior alternative for maintaining organ viability.