Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A rodent model for pulmonary paragonimiasis.

Kanwar Narain1, K Rekha Devi, J Mahanta

  • 1Regional Medical Research Centre, N.E. Region, Indian Council of Medical Research, P.O.B. 105, Dibrugarh 786 001, Assam, India.

Parasitology Research
|October 8, 2003
PubMed
Summary

Researchers developed a rat model for pulmonary paragonimiasis using Paragonimus heterotremus. The study observed adult worms in the lungs and immature flukes in skeletal muscles, establishing a new model for this parasitic lung disease.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Post-hospitalized Health Conditions of Covid-19 patients: A Cross-sectional study in Bangladesh.

Mymensingh medical journal : MMJ·2026
Same author

Prevalence and immunoreactivity of Schistosoma spindale-induced cercarial dermatitis among paddy farmers in Assam, India: A comprehensive molecular and proteomic study.

Parasitology international·2026
Same author

Genetic susceptibility and gene-environment interactions in gastric cancer among ethnic populations of Northeast India.

Scientific reports·2026
Same author

Anopheles maculatus s.l as potential malaria vectors with opportunistic feeding in Meghalaya, Northeast India.

Scientific reports·2026
Same author

Assessment of exonic polymorphism of <i>IDH2</i>, <i>KRAS1</i>, <i>TP53</i>, and <i>BRAF2</i> using PCR-RFLP in hepatocellular carcinoma: a case-control study from Arunachal Pradesh and Sikkim.

Personalized medicine·2026
Same author

Correction: Detection of a sympatric cryptic species mimicking Aedes albopictus (Diptera: Culicidae) in dengue and Chikungunya endemic forest villages of Tripura, India, posing a daunting challenge for vector research.

Scientific reports·2025

Area of Science:

  • Parasitology
  • Infectious Diseases
  • Animal Models

Background:

  • Pulmonary paragonimiasis is a parasitic lung infection caused by Paragonimus trematodes.
  • An effective animal model is crucial for studying the pathogenesis and treatment of this disease.

Purpose of the Study:

  • To establish and characterize a novel animal model for pulmonary paragonimiasis.
  • To utilize the Indian strain of Paragonimus heterotremus for modeling the infection in rats.

Main Methods:

  • Outbred Wistar rats were infected with metacercariae of Paragonimus heterotremus.
  • The parasite was isolated from naturally infected freshwater crabs (Barytelphusa lugubris) from Arunachal Pradesh, India.
  • Infected rats were analyzed to determine parasite localization and development.

Related Experiment Videos

Main Results:

  • Encapsulated adult Paragonimus heterotremus worms were found in the lungs and pleural cavity of infected rats.
  • A portion of the flukes migrated to and remained underdeveloped in the skeletal muscles.
  • The study successfully established a pulmonary paragonimiasis model in rats.

Conclusions:

  • The Wistar rat model effectively replicates key aspects of pulmonary paragonimiasis.
  • This model provides a valuable tool for future research into Paragonimus heterotremus infections.
  • The findings highlight the migratory behavior of P. heterotremus within the host.