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Related Experiment Videos

Dopamine transporter: basic aspects and neuroimaging.

Paola P Piccini1

  • 1MRC Clinical Sciences Centre, and Division of Neuroscience, Faculty of Medicine, Imperial College, Hammersmith Hospital, London, United Kingdom. paola.piccini@csc.mrc.ac.uk

Movement Disorders : Official Journal of the Movement Disorder Society
|October 8, 2003
PubMed
Summary

The dopamine transporter (DAT) is crucial for regulating dopamine signaling. Neuroimaging techniques like PET and SPECT visualize DAT distribution, aiding in understanding brain health and disease.

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Area of Science:

  • Neuroscience
  • Molecular Biology
  • Medical Imaging

Background:

  • The plasma membrane dopamine transporter (DAT) is a key molecule exclusively found in dopamine neurons.
  • DAT regulates dopamine neurotransmission by recapturing released dopamine.
  • It plays a critical role in dopaminergic signaling intensity.

Purpose of the Study:

  • To discuss the characteristics of various DAT radiotracers.
  • To explore factors influencing DAT transporters, including age, gender, smoking, and dopaminergic drugs.
  • To examine the implications of these factors in neuroimaging studies of dopaminergic function.

Main Methods:

  • Utilizes Positron Emission Tomography (PET) and Single-Photon Emission Computed Tomography (SPECT) for in vivo DAT distribution assessment.

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  • Reviews existing literature on DAT radiotracers and their properties.
  • Analyzes the impact of physiological and pharmacological factors on DAT.

    • Main Results:

    • PET and SPECT are valuable tools for studying in vivo DAT distribution.
    • Factors like age, gender, smoking, and certain drugs can modify DAT levels.
    • Understanding these modifications is essential for accurate neuroimaging interpretation.

    Conclusions:

    • DAT imaging provides insights into nigrostriatal dopaminergic function in health and disease.
    • Radiotracer characteristics and influencing factors must be considered for reliable DAT imaging.
    • This knowledge is vital for evaluating neuroimaging studies and advancing our understanding of dopamine-related disorders.