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Updated: Aug 30, 2026

Protocol for Long Duration Whole Body Hyperthermia in Mice
Published on: August 25, 2012
[Malignant hyperthermia]
Fritz Zimprich1, Hans Georg Kress, Josef Zeitlhofer
1Universitätsklinik für Neurologie, Wien, Osterreich.
Abstract:
Malignant hyperthermia is an autosomal dominant disorder of the skeletal muscle that predisposes affected individuals to a life-threatening hypermetabolic reaction in response to volatile anaesthetics and depolarizing muscle relaxants. The underlying heterogeneous genetic defects are mainly point mutations within the ryanodine receptor gene of the sarcoplasmic reticulum. Following the introduction of efficient diagnostic and therapeutic tools--the in vitro contracture test and intravenous treatment with dantrolene--a dramatic decline in mortality rates has been observed. The association of malignant hyperthermia-like reactions with other neuromuscular disorders requires the collaboration of several clinical disciplines to achieve a timely recognition of this still life-threatening disorder.
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