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Related Experiment Videos

Rofecoxib-beta-cyclodextrin inclusion complex for solubility enhancement.

S Rawat1, S K Jain

  • 1Y. B. Chavan College of Pharmacy, Rouza Bagh, M.S. Aurangabad, India. swati_rawat_001@rediffmail.com

Die Pharmazie
|October 9, 2003
PubMed
Summary
This summary is machine-generated.

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Rofecoxib and beta-cyclodextrin form a 1:1 complex, significantly enhancing rofecoxib

Area of Science:

  • Pharmaceutical Sciences
  • Drug Delivery Systems

Background:

  • Rofecoxib, a non-steroidal anti-inflammatory drug (NSAID), suffers from poor aqueous solubility.
  • Improving the solubility and dissolution rate of rofecoxib is crucial for its therapeutic efficacy.

Purpose of the Study:

  • To investigate the complexation of rofecoxib with beta-cyclodextrin.
  • To evaluate the potential of beta-cyclodextrin to enhance the solubility and dissolution rate of rofecoxib in both aqueous and solid states.

Main Methods:

  • Phase solubility studies were conducted to determine complex formation in aqueous solution.
  • Solid inclusion complexes were prepared using the kneading method at various molar ratios.
  • Differential scanning calorimetry (DSC) was employed to characterize the solid complexes.

Related Experiment Videos

Main Results:

  • Phase solubility studies confirmed the formation of a 1:1 complex between rofecoxib and beta-cyclodextrin with an apparent stability constant of 769 M⁻¹.
  • DSC analysis verified the formation of solid inclusion complexes.
  • The prepared solid inclusion complexes demonstrated a significantly higher dissolution rate compared to the physical mixture and pure rofecoxib.

Conclusions:

  • Beta-cyclodextrin effectively forms inclusion complexes with rofecoxib in both solution and solid states.
  • Complexation with beta-cyclodextrin is a viable strategy to improve the solubility and dissolution rate of rofecoxib.
  • The enhanced dissolution characteristics of the complexes hold promise for improved rofecoxib drug delivery.