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Updated: Aug 30, 2026

Formation of Dispersible Taohong Siwu Tablets
Published on: February 3, 2023
Modified release bi-layered tablet of melatonin using beta-cyclodextrin
A Kumar1, S P Agarwal, R Khanna
1Department of Pharmaceutics, Jamia Hamdard (Hamdard University), Hamdard Nagar, New Delhi, India.
Abstract:
A modified release bi-layered tablet of melatonin incorporating a fast release fraction consisting of melatonin-beta-cyclodextrin inclusion complex and a slow release fraction containing melatonin in HPMC K15M and Carbopol 971 P matrices was prepared. The formulation developed showed an initial burst followed by a near zero order release pattern for a period of 8 h. The drug content, physical characteristics and the release profile were unaffected after 3 months of an accelerated stability study at 40 degrees C and 75% relative humidity.
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