Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Resolving multiple epigenetic pathways to adolescent depression.

Lindon Eaves1, Judy Silberg, Alaattin Erkanli

  • 1Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University School of Medicine, Richmond 23298-0003, USA.

Journal of Child Psychology and Psychiatry, and Allied Disciplines
|October 9, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Endometrial thickness in patients with postmenopausal bleeding and endometrial cancer: A retrospective cohort study.

Gynecologic oncology reports·2026
Same author

What is the risk of HCC in hypervascular LI-RADS 3 observations without ancillary features in routine clinical practice?

Abdominal radiology (New York)·2026
Same author

Are two really better than one? A retrospective study comparing monotherapy versus combination therapy for <i>Stenotrophomonas maltophilia</i> infections.

Microbiology spectrum·2026
Same author

Pharmacy Technician Impact on Access to High-Cost Heart Failure Pharmacotherapy.

The Annals of pharmacotherapy·2026
Same author

Risk Factors for Breakthrough Cytomegalovirus Infections While on Prophylaxis in Kidney and Pancreas Transplant Recipients.

Transplant infectious disease : an official journal of the Transplantation Society·2026
Same author

The Impact of a Protocol on Equitable Labor and Delivery Substance Use Screening: A Retrospective Cohort Study.

American journal of perinatology·2025
Same journal

Co-development of ADHD symptoms and emotional problems from childhood to adulthood: predictors and developmental outcomes.

Journal of child psychology and psychiatry, and allied disciplines·2026
Same journal

Individualized EEG functional connectivity predicts clinical symptoms in ADHD, dyslexia, and their comorbidity.

Journal of child psychology and psychiatry, and allied disciplines·2026
Same journal

Mechanism-based subtypes of problematic use of the internet and corresponding neurobehavioral characteristics among children and adolescents.

Journal of child psychology and psychiatry, and allied disciplines·2026
Same journal

Personally meaningful life events from adolescence to young adulthood: a longitudinal natural language processing analysis.

Journal of child psychology and psychiatry, and allied disciplines·2026
Same journal

A double-blind randomized controlled trial of personalized upper-alpha neurofeedback in children with ADHD.

Journal of child psychology and psychiatry, and allied disciplines·2026
Same journal

Self-administered single-session interventions for mental health in young people: A systematic review and meta-analysis.

Journal of child psychology and psychiatry, and allied disciplines·2026
See all related articles

Genetic differences in anxiety influence depression risk. Genes impact sensitivity to life events (G x E) and exposure to adverse environments (rGE), crucial for understanding complex behaviors.

Area of Science:

  • Behavioral genetics
  • Psychiatric genetics
  • Twin studies

Background:

  • Genotype x environment interaction (G x E) occurs when genes affect environmental sensitivity.
  • Genotype-environment correlation (rGE) arises when genes influence environmental exposure.
  • Analyzing G x E and rGE simultaneously in humans is complex due to correlated genetic and environmental effects.

Purpose of the Study:

  • To model the interplay of genes, environment, G x E, and rGE in the development of depression.
  • To investigate the relationship between pre-pubertal anxiety and post-pubertal depression in female twins.
  • To resolve distinct genetic and environmental pathways influencing depression.

Main Methods:

  • Markov Chain Monte Carlo (MCMC) approach.

Related Experiment Videos

  • Analysis of three pathways: main effects of genes and environment, G x E, and rGE.
  • Utilized twin data to examine genetic and environmental influences on depression and anxiety.

    • Main Results:

    • A model incorporating G x E and rGE provided significant parameter estimates.
    • Excluding G x E or rGE led to overestimation of environmental effects.
    • Both G x E and rGE are significant factors in the development of depression.

    Conclusions:

    • Genetic factors in anxiety predict later genetic differences in depression.
    • Genes associated with early anxiety increase sensitivity (G x E) to adverse life events.
    • Genes linked to early anxiety also increase exposure (rGE) to depressogenic environments.