Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: Jul 9, 2026

Assembly of Gold Nanorods into Chiral Plasmonic Metamolecules Using DNA Origami Templates

Assembly of Gold Nanorods into Chiral Plasmonic Metamolecules Using DNA Origami Templates

Published on: March 5, 2019

DNA-templated metal catalysis.

Jens Brunner¹, Andriy Mokhir, Roland Kraemer

¹Anorganisch-Chemisches Institut, Universität Heidelberg, Im Neuenheimer Feld 270, 69120 Heidelberg, Germany.

Journal of the American Chemical Society

|October 9, 2003

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Hybrid Aminoferrocenes With Nitrate Esters for In Situ Peroxynitrite Generation: Complex Interplay Between Redox Chemistry, NO-Donor Reactivity, and Aminoferrocene Activation Influences In Vitro Anticancer Activity.

Chembiochem : a European journal of chemical biology·2026

Same author

A "turn-on" chemodosimeter for detection of Cu<sup>2+</sup> in living cells.

Dalton transactions (Cambridge, England : 2003)·2025

Same author

Reaction of N-Ferrocenylcarbamates with Nitric Oxide: An Application for Detection of Inflammatory Sites In Vivo.

ChemMedChem·2025

Same author

Targeting Lysosomal Thiols for Immunogenic Cancer Cell Death.

Angewandte Chemie (International ed. in English)·2024

Same author

Red Fluorescent Aminoferrocene (Pro)Drugs for in Cellulo and in Vivo Imaging.

Chemistry (Weinheim an der Bergstrasse, Germany)·2024

Same author

A concept of dual-responsive prodrugs based on oligomerization-controlled reactivity of ester groups: an improvement of cancer cells <i>versus</i> neutrophils selectivity of camptothecin.

RSC medicinal chemistry·2024

DNA templates accelerate ester hydrolysis catalyzed by peptide nucleic acid-copper complexes. This DNA-templated reaction combines sequence selectivity with metal catalysis for enhanced reaction rates.

Area of Science:

Biochemistry
Chemical Biology
Catalysis

Background:

Oligo-peptide nucleic acids (PNA) offer unique structural and binding properties.
Metal complexes are versatile catalysts for various chemical transformations.
DNA-templated reactions enable sequence-specific molecular recognition and catalysis.

Purpose of the Study:

To investigate the effect of DNA templates on the catalytic activity of PNA-metal complexes.
To explore the synergy between DNA-templated reactions and metal catalysis.
To develop a system for accelerated and sequence-selective ester hydrolysis.

Main Methods:

Synthesis of a Cu(II) complex attached to an oligo-peptide nucleic acid (PNA).
Assay of ester hydrolysis in the presence and absence of a complementary DNA template.

More Related Videos

DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications

DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications

Published on: September 27, 2019

Single-Molecule Surface-Enhanced Raman Scattering Measurements Enabled by Plasmonic DNA Origami Nanoantennas

Single-Molecule Surface-Enhanced Raman Scattering Measurements Enabled by Plasmonic DNA Origami Nanoantennas

Published on: July 21, 2023

Related Experiment Videos

Last Updated: Jul 9, 2026

Assembly of Gold Nanorods into Chiral Plasmonic Metamolecules Using DNA Origami Templates

Assembly of Gold Nanorods into Chiral Plasmonic Metamolecules Using DNA Origami Templates

Published on: March 5, 2019

DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications

DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications

Published on: September 27, 2019

Single-Molecule Surface-Enhanced Raman Scattering Measurements Enabled by Plasmonic DNA Origami Nanoantennas

Single-Molecule Surface-Enhanced Raman Scattering Measurements Enabled by Plasmonic DNA Origami Nanoantennas

Published on: July 21, 2023

Kinetic analysis to determine the rate acceleration.

Main Results:

The hydrolysis of an ester substrate was significantly accelerated by the PNA-Cu(II) catalyst.
The presence of a complementary DNA template enhanced the reaction rate up to 485-fold.
The catalytic system demonstrated sequence selectivity dictated by the DNA template.

Conclusions:

DNA-templated reactions can dramatically enhance the efficiency of PNA-based catalysts.
This approach integrates sequence recognition, signal amplification via multiple turnover, and metal catalysis.
The findings open avenues for developing novel DNA-responsive catalytic systems.