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Pharmacokinetic-pharmacodynamic modeling of daurisoline and dauricine in beagle dogs
Shao-Jun Shi1, Hui Chen, Shi-Fen Gu
1Department of Pharmacology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. sjshi1@163.com.
Aim:
To study the combined pharmacokinetic-pharmacodynamic (PK-PD) model of daurisoline and dauricine, and compare their effects on cardiac electrophsiology, blood pressure, and hemodynamics in beagle dogs.
Methods:
The plasma drug concentration was determined by the reversed-phase HPLC method and the effects on cardiac and hemodynamics were recorded by polygraph. The pharmacokinetic and PK-PD model parameters were calculated.
Results:
The pharmacokinetics were best fitted to a two-compartment open model, and the relationship between effect and effect compartment concentration of both drugs could be represented by the sigmoid-E(max) model. There were no significant differences in main pharmacokinetics and PK-PD parameters between the two drugs.
Conclusion:
No statistically different kinetic disposition characteristics and potencies of inhibitory effects on myocardial function of daurisoline and dauricine were found in beagle dogs.
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