Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Putative caveolin-binding sites in SARS-CoV proteins.

Quan-Cai Cai1, Qing-Wu Jiang, Gen-Ming Zhao

  • 1School of Public Health, Fudan University, Shanghai 200032, China. qccai@smmu.edu.cn

Acta Pharmacologica Sinica
|October 9, 2003
PubMed
Summary

This study identified potential binding sites between SARS-CoV proteins and caveolin-1 using bioinformatics and molecular modeling. These interactions suggest caveolin-1 may act as a receptor, influencing SARS-CoV infection and replication.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Molecular evolution and spatial transmission of severe fever with thrombocytopenia syndrome virus.

Nature communications·2026
Same author

Fever clinic construction and management targeted to prevention and control of healthcare-associated respiratory viral infections in Jiangsu, China: A cross-sectional observational study.

PloS one·2024
Same author

Increased circulating level of interleukin-6 and CD8<sup>+</sup> T cell exhaustion are associated with progression of COVID-19.

Infectious diseases of poverty·2020
Same author

[Influence of online social software on HIV transmission among men who have sex with men].

Zhonghua nan ke xue = National journal of andrology·2020
Same author

Prognostic value of preoperative carcinoembryonic antigen/tumor size in rectal cancer.

World journal of gastroenterology·2019
Same author

Helvolic acid attenuates osteoclast formation and function via suppressing RANKL-induced NFATc1 activation.

Journal of cellular physiology·2018

Area of Science:

  • Virology
  • Molecular Biology
  • Biochemistry

Background:

  • Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) is a significant human pathogen.
  • Understanding host-pathogen interactions is crucial for developing therapeutic strategies.

Purpose of the Study:

  • To investigate protein-protein interactions between SARS-CoV proteins and human caveolin-1.
  • To identify specific caveolin-binding sites within SARS-CoV proteins.

Main Methods:

  • Bioinformatic analysis using amino acid motif searching to predict potential caveolin-binding domains.
  • Molecular modeling and docking simulations to confirm interactions between SARS-CoV proteins and caveolin-1.

Main Results:

  • Thirty-six potential caveolin-binding motifs were identified in SARS-CoV proteins.

Related Experiment Videos

  • Eight specific caveolin-binding sites were confirmed through molecular modeling and simulation.
  • These sites are located in key SARS-CoV proteins including replicase 1AB, spike protein, orf3 protein, and M protein.

    • Conclusions:

    • Caveolin-1 may function as a host receptor for SARS-CoV proteins.
    • These interactions could play a role in SARS-CoV infection, viral replication, assembly, and budding.