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Related Concept Videos

Replicative Cell Senescence02:15

Replicative Cell Senescence

Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds the telomeric...
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In eukaryotic cells, DNA replication is highly conserved and tightly regulated. Multiple linear chromosomes must be duplicated with high fidelity before cell division, so there are many proteins that fulfill specialized roles in the replication process. Replication occurs in three phases: initiation, elongation, and termination, and ends with two complete sets of chromosomes in the nucleus.
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Related Experiment Video

Updated: May 8, 2026

Studying Age-dependent Genomic Instability using the S. cerevisiae Chronological Lifespan Model
08:46

Studying Age-dependent Genomic Instability using the S. cerevisiae Chronological Lifespan Model

Published on: September 29, 2011

Increased genome instability in aging yeast.

Serge Gravel1, Stephen P Jackson

  • 1The Wellcome Trust/Cancer Research, UK.

Cell
|October 9, 2003
PubMed
Summary
This summary is machine-generated.

Aged yeast cells show increased loss of heterozygosity due to impaired DNA double-strand break repair. This research reveals how aging contributes to genomic instability in eukaryotic cells.

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Related Experiment Videos

Last Updated: May 8, 2026

Studying Age-dependent Genomic Instability using the S. cerevisiae Chronological Lifespan Model
08:46

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Published on: September 29, 2011

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Published on: August 20, 2013

Combining Magnetic Sorting of Mother Cells and Fluctuation Tests to Analyze Genome Instability During Mitotic Cell Aging in Saccharomyces cerevisiae
11:08

Combining Magnetic Sorting of Mother Cells and Fluctuation Tests to Analyze Genome Instability During Mitotic Cell Aging in Saccharomyces cerevisiae

Published on: October 16, 2014

Area of Science:

  • Genetics
  • Molecular Biology
  • Cell Biology

Background:

  • Genomic instability is a hallmark of aging.
  • Understanding the molecular mechanisms underlying age-related genomic instability is crucial.

Purpose of the Study:

  • To investigate the relationship between aging and genomic instability in yeast.
  • To determine the specific DNA repair processes affected in aged cells.

Main Methods:

  • Utilized the yeast model organism (Saccharomyces cerevisiae).
  • Assessed rates of loss of heterozygosity in aged versus young cells.
  • Examined DNA double-strand break detection and repair pathways.

Main Results:

  • Aged yeast cells exhibited significantly higher rates of loss of heterozygosity.
  • This increase was correlated with a diminished capacity to detect and repair DNA double-strand breaks.
  • Evidence suggests a decline in DNA repair efficiency with cellular age.

Conclusions:

  • Aging in yeast is associated with increased genomic instability.
  • Impaired DNA double-strand break repair is a key factor contributing to this instability.
  • These findings offer insights into the aging process and its impact on genome integrity in eukaryotes.