Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Microarray experimental design: power and sample size considerations.

M C K Yang1, J J Yang, R A McIndoe

  • 1Department of Statistics, University of Florida, Gainesville, Florida 32611, USA. yang@stat.ufl.edu

Physiological Genomics
|October 9, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Association between sex hormone levels and high-sensitivity C-reactive protein in older adults aged 65 years and above in 18 longevity areas in China].

Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi·2026
Same author

[Supratentorial papillary glioneuronal tumors: a clinicopathological and genetic analysis of six cases].

Zhonghua bing li xue za zhi = Chinese journal of pathology·2026
Same author

[Association between sex hormone levels and sarcopenia risk among older adults over 65 years old in longevity areas of China].

Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]·2026
Same author

[Risk assessment of subsequent drug resistance in patients with chemoresistant gestational trophoblastic neoplasia].

Zhonghua fu chan ke za zhi·2026
Same author

[Association between physical activity and non-alcoholic fatty liver disease among adults aged 65 and above in longevity regions of China].

Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]·2026
Same author

[Association between thyroid hormone levels and body mass index, waist circumference and body composition in older adults aged 65 years and above in 18 longevity areas in China].

Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi·2026
Same journal

Regulation of RGS2 is an important piece to the puzzle of syncytiotrophoblast dysfunction in preeclampsia.

Physiological genomics·2026
Same journal

Maternal Estradiol Impacts Fetal HPA Axis and Pulmonary Transcriptomes in Sheep.

Physiological genomics·2026
Same journal

OBESITY AS AN EPIGENETIC CONTINUUM: DEVELOPMENTAL ROOTS, ADIPOSE REMODELING, AND THE LIMITS OF REVERSIBILITY.

Physiological genomics·2026
Same journal

<i>Akkermansia muciniphila</i>: a member of the gut microbiota that modulates intestinal stem cell function.

Physiological genomics·2026
Same journal

Differential gene transcription following intravenous injection of air bubbles in rats with varying resistance to decompression sickness (DCS).

Physiological genomics·2026
Same journal

Genomic informational field theory to identify genetic associations of a complex trait using a small sample size.

Physiological genomics·2026
See all related articles

Determining adequate sample size is crucial for reliable gene expression analysis. This study presents statistical methods to ensure sufficient subjects for accurate detection of differentially expressed genes in microarray experiments.

Area of Science:

  • Bioinformatics
  • Systems Biology
  • Statistical Genetics

Background:

  • High-throughput microarray technology is vital for systems biology research.
  • Growing microarray data necessitates robust statistical analysis.
  • Determining appropriate sample sizes for microarray studies remains under-addressed.

Purpose of the Study:

  • To develop statistical methods for calculating sufficient sample sizes in gene expression studies.
  • To optimize sample size determination for minimizing false discovery rates and maximizing detection power.

Main Methods:

  • Statistical analysis for sample size determination in two experimental designs.
  • Design 1: Comparison of two groups at a single time point.
  • Design 2: Comparison of two groups with sequential time points.

Related Experiment Videos

Main Results:

  • Methods presented allow for calculation of sample sizes to control false discovery rates.
  • High statistical power is maintained for detecting differentially expressed genes.
  • The methods are adaptable to complex experimental designs.

Conclusions:

  • Statistical methods are provided to determine adequate sample sizes for microarray gene expression studies.
  • These methods enhance the reliability and reproducibility of systems biology research.
  • Available computational tools support the application of these statistical approaches.