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Pergolide mesylate form II.

Alexandr Jegorov1, Zdenek Horák, Jan Cejka

  • 1IVAX Pharmaceuticals sro, Research Unit, Branisovská 31, 370 05 Ceské Budejovice, Czech Republic. alexandr_jegorov@ivax-cz.com

Acta Crystallographica. Section C, Crystal Structure Communications
|October 9, 2003
PubMed
Summary

A new crystalline form of pergolide mesylate, known as form II, has been identified. This unique trigonal crystal system differs in its hydrogen bonding from form I, yet maintains a similar pergolide structure.

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Area of Science:

  • Crystallography
  • Solid-state chemistry
  • Pharmaceutical science

Background:

  • Pergolide mesylate is an ergot derivative used therapeutically.
  • Understanding different crystalline forms (polymorphs) is crucial for drug stability and bioavailability.
  • Ergot derivatives often exhibit complex solid-state properties.

Purpose of the Study:

  • To report the discovery and characterization of a new polymorph of pergolide mesylate.
  • To investigate the crystallographic properties of this new form.
  • To compare its structural features with previously known forms.

Main Methods:

  • Single-crystal X-ray diffraction was used to determine the crystal structure.
  • Crystallization experiments were performed to obtain the new polymorph.

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  • Structural analysis focused on hydrogen bonding and molecular conformation.

    • Main Results:

    • A new polymorph, pergolide mesylate form II, was successfully isolated and characterized.
    • Form II crystallizes in the trigonal system, a unique observation among ergot derivatives.
    • The hydrogen-bond network in form II is distinct from form I.
    • The conformation of the pergolide molecule remains largely conserved across different forms.

    Conclusions:

    • The identification of pergolide mesylate form II expands the understanding of its solid-state landscape.
    • The unique trigonal crystallization highlights novel packing possibilities for ergot derivatives.
    • Despite differences in crystal packing and hydrogen bonding, the core pergolide structure is conformationally stable.