New way to deliver fluids: endoscopic jet injection into the beagle prostate
Gerald Haupt1, Angela Haupt, Klaus-Dieter Richter
1Department of Urology, University of Cologne, Cologne, Germany.
Purpose:
Local therapy of the prostate could have a role in the treatment of benign prostatic hyperplasia as well as prostate cancer. Endoscopic jet injection could simplify these treatments. We evaluated the tissue effects of endoscopic jet injection in an animal model.
Materials And Methods:
An endoscopic jet injector was developed. In 12 beagle dogs the prostate was injected with single shot and continuous mode jet injection. Macroscopic and histological analysis was performed 0, 2 and 14 days after jet injection.
Results:
Jet injection allowed complete penetration of the beagle prostate. The single shot technique resulted in only minimal tissue effects. However, the continuous mode led to major tissue damage, even complete aseptic necrosis, in the injected area.
Conclusions:
A new method for endoscopic application of fluids is described. Depending on the jet injection technique it could be used to apply pharmaceutical agents or plasmids, and/or induce aseptic necrosis.
