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Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
07:36

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats

Published on: November 20, 2015

[Posterior reversible encephalopathy in infancy]

H A Arroyo1, L A Gañez, N Fejerman

  • 1Servicio de Neurología, Hospital de Pediatria SAMIC, Prof Dr JP Garrahan, Buenos Aires, Argentina. hugoarroyo@arnet.com.ar

Revista De Neurologia
|October 9, 2003
PubMed

Insights

Posterior reversible encephalopathy (PRE) in children presents with seizures, headaches, and visual changes, often linked to acute hypertension. Prompt antihypertensive treatment resolves symptoms and normalizes neuroimaging findings.

Area of Science:

  • Neurology
  • Pediatrics
  • Radiology

Context:

  • Posterior reversible encephalopathy (PRE) is a clinical-radiological syndrome initially described in adults.
  • Commonly associated with arterial hypertension (AHT) and immunosuppressive therapies.
  • PRE is characterized by seizures, headache, visual disturbances, altered awareness, and neuroimaging anomalies.

Purpose:

  • To describe the clinical and radiological characteristics of PRE in pediatric patients.
  • To highlight the association between AHT and PRE in children.
  • To evaluate the diagnostic and therapeutic implications of PRE in a pediatric cohort.

Summary:

  • Seven pediatric patients diagnosed with PRE were analyzed.
  • All patients presented with acute arterial hypertension, predominantly associated with kidney disease.
  • Common symptoms included vomiting, headaches, seizures, visual disorders, and decreased awareness; neuroimaging revealed asymmetric parieto-occipital and cortical-subcortical involvement.

Impact:

  • This study emphasizes the importance of considering PRE in pediatric patients presenting with neurological symptoms and acute hypertension.
  • Effective management of arterial hypertension is crucial for symptom resolution and normalization of neuroimaging findings.
  • Early diagnosis and treatment of PRE in children can lead to complete recovery and prevent long-term neurological sequelae.
Abstract

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