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Interventional Diagnostic Procedure: A Practical Guide for the Assessment of Coronary Vascular Function
Published on: March 15, 2022
[Interventional radiology, angioplasty and TIPS in Budd-Chiari syndrome]
O Núñez1, G de la Cruz, J Molina
1Servicio de Aparato Digestivo. Hospital General Universitario Gregorio Marañón. Madrid. España.
Insights
Transjugular intrahepatic portosystemic shunt (TIPS) and balloon angioplasty offer effective treatment for Budd-Chiari syndrome, improving patient outcomes and serving as alternatives to surgery.
Area of Science:
- Interventional Radiology
- Hepatology
- Vascular Surgery
Background:
- Budd-Chiari syndrome involves hepatic vein obstruction.
- Surgical shunting is a traditional treatment.
- Interventional radiology presents alternative therapeutic options.
Purpose of the Study:
- To evaluate the efficacy of percutaneous balloon angioplasty and transjugular intrahepatic portosystemic shunt (TIPS) in Budd-Chiari syndrome treatment.
- To compare these interventional techniques against surgical options.
Main Methods:
- Retrospective analysis of 11 patients with Budd-Chiari syndrome.
- Seven patients underwent either percutaneous balloon angioplasty (2) or TIPS (5).
- Efficacy assessed by clinical improvement, ascites resolution, and Child-Pugh score changes.
Main Results:
- Percutaneous balloon angioplasty yielded favorable outcomes with ascites resolution in two patients with isolated stenosis.
- Transjugular intrahepatic portosystemic shunt (TIPS) resulted in clinical improvement and ascites resolution in four of five patients, with significant Child-Pugh score reduction.
- One patient died post-TIPS, and two died from underlying disease during follow-up; no shunt malfunction was noted.
Conclusions:
- Budd-Chiari syndrome management requires a multidisciplinary and individualized approach.
- Transjugular intrahepatic portosystemic shunt (TIPS) is a viable decompressive option for medically refractory cases, serving as an alternative to surgical shunting.
- Liver transplantation remains an option for patients unresponsive to interventional techniques.
Introduction:
Budd-Chiari syndrome consists of complete or partial obstruction of the hepatic veins. Many treatment options are available; new interventional radiology techniques may play an important role as an alternative to surgical shunting.
Patients And Method:
Of 11 patients diagnosed with Budd-Chiari syndrome, 7 were treated with percutaneous balloon angioplasty or transjugular intrahepatic portosystemic shunt (TIPS) (2 and 5 patients, respectively). The efficacy of both techniques in the treatment of this syndrome was evaluated.
Results:
Two patients presented significant isolated stenosis of a suprahepatic vein and underwent percutaneous balloon angioplasty. In both patients outcome was favorable with resolution of ascites. Five patients underwent TIPS and four showed clinical improvement with significant reduction in Child-Pugh score (p < 0.05) and resolution of ascites. No shunt malfunction was detected during follow-up. One patient showed no improvement after placement of TIPS and died soon after the procedure and a further two died from their underlying disease during follow-up.
Conclusions:
Treatment of Budd-Chiari syndrome requires multidisciplinary evaluation and should be individualized. In patients with Budd-Chiari syndrome uncontrolled by medical therapy, TIPS may become the decompressive method of choice as an alternative to surgical shunting. Liver transplantation may be reserved to patients in whom these techniques are ineffective.
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