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[Skin ageing and its prevention].

Thierry Passeron1, Jean-Paul Ortonne

  • 1Service de dermatologie, CHU, Hôpital Archet 2, Nice.

Presse Medicale (Paris, France : 1983)
|October 10, 2003
PubMed
Summary

Skin aging results from intrinsic and extrinsic factors like UV radiation. Prevention involves sunscreens and lifestyle changes, while retinoids offer effective treatment options.

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Dermatology and therapy·2026

Area of Science:

  • Dermatology and cellular biology
  • Investigating the molecular mechanisms of skin aging

Context:

  • Skin aging is influenced by intrinsic (chronological) and extrinsic (photo-aging) factors.
  • UV radiation (UVA and UVB), tobacco, and free radicals are key contributors to extrinsic skin aging.
  • Photo-aging involves direct DNA damage from UVB and free radical-induced damage from UVA.

Purpose:

  • To elucidate the factors contributing to skin aging.
  • To understand the mechanisms of intrinsic and extrinsic skin aging.
  • To explore preventive and therapeutic strategies for skin aging.

Summary:

  • Intrinsic aging involves chronological processes common to all organs.
  • Extrinsic factors, primarily UV radiation, cause photo-aging through DNA damage and matrix degradation.
  • Aging impairs skin's defense, healing, and thermoregulation, leading to clinical manifestations and increased cancer risk.

Impact:

  • Photo-aging serves as a marker for photo-carcinogenesis risk, necessitating vigilant clinical monitoring.
  • Effective prevention strategies include broad-spectrum sunscreens (UVA/UVB) and lifestyle modifications.
  • Retinoids are a valuable therapeutic option for both preventing and treating skin aging due to their safety and efficacy.

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