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Tuberculous peritonitis mimicking peritonitis carcinomatosis: a case report.

Jia-Feng Wu1, Hwa-Jung Li, Ping-Ing Lee

  • 1Department of Paediatrics, National Taiwan University Hospital, No. 7 Chung-Shan S. Road, Taipei, Taiwan.

European Journal of Pediatrics
|October 10, 2003
PubMed
Summary
This summary is machine-generated.

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Tuberculous peritonitis, initially suspected as peritonitis carcinomatosis due to elevated cancer antigen-125 (CA-125), was diagnosed via laparoscopy. CA-125 levels decreased with anti-tuberculosis treatment, indicating its potential as a marker for disease activity.

Area of Science:

  • Infectious Diseases
  • Oncology
  • Gastroenterology

Background:

  • Tuberculous peritonitis is a significant cause of morbidity, particularly in endemic areas.
  • It often presents with non-specific symptoms mimicking other abdominal pathologies, complicating diagnosis.
  • Elevated cancer antigen-125 (CA-125) is typically associated with ovarian cancer but can be raised in other conditions.

Observation:

  • A 13-year-old female presented with symptoms suggestive of peritonitis, including fever and abdominal distension.
  • Imaging revealed omental cake and peritoneal thickening, leading to initial suspicion of peritonitis carcinomatosis.
  • Significantly elevated serum CA-125 levels (1248.5 U/ml) were noted.

Findings:

  • Diagnostic laparoscopy identified peritoneal tubercles, and pathology confirmed granulomatous inflammation.

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  • Ascitic fluid culture isolated Mycobacterium tuberculosis, establishing the diagnosis of tuberculous peritonitis.
  • Following anti-tuberculosis treatment, the patient's symptoms resolved, and CA-125 levels decreased to 10.2 U/ml.
  • Implications:

    • This case highlights the diagnostic challenge of tuberculous peritonitis, especially when presenting with elevated CA-125.
    • Serum CA-125 levels may serve as a valuable non-invasive marker for monitoring disease activity and treatment response in tuberculous peritonitis.
    • Further research is warranted to validate CA-125 as a reliable biomarker in this condition.