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Related Experiment Videos

Ferumoxtran-10 Advanced Magnetics.

William Leenders1

  • 1University Medical Centre St Radboud, Department of Pathology, 6500 HB Nijmegen, Netherlands. w.leenders@pathol.umcn.nl

Idrugs : the Investigational Drugs Journal
|October 10, 2003
PubMed
Summary

Ferumoxtran-10 (Combidex) is an ultra-small superparamagnetic iron oxide agent. It is being developed for enhanced lymph node imaging using molecular resonance imaging.

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Area of Science:

  • Biomedical Imaging
  • Nanotechnology
  • Radiology

Background:

  • Superparamagnetic iron oxide nanoparticles (SPIONs) are utilized as contrast agents in magnetic resonance imaging (MRI).
  • Ferumoxtran-10 (Combidex) is an ultra-small SPION formulation developed for enhanced imaging applications.

Purpose of the Study:

  • To describe the development and potential application of Ferumoxtran-10 (Combidex) as a contrast agent.
  • To highlight its primary indication for lymph node imaging.

Main Methods:

  • Ferumoxtran-10 is an ultra-small superparamagnetic iron oxide nanoparticle.
  • It functions as a molecular resonance imaging contrast agent.

Main Results:

  • Ferumoxtran-10 is under development by Advanced Magnetics Ltd and Guerbet.
  • Its principal indication is for lymph node imaging.

Conclusions:

  • Ferumoxtran-10 shows promise as a novel contrast agent for lymph node visualization.
  • Further development is ongoing for its clinical application in molecular resonance imaging.

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