Jove
Visualize
Contact Us

Related Experiment Videos

[The relation between morphologic and functional airway changes in bronchial asthma].

J C Kips1

  • 1Centrum voor Medische Genetica-Dienst Klinische Genetica Faculteit Geneeskunde en Gezondheidswetenschappen-UZ Gent De Pintelaan, 185-B 9000 Gent.

Verhandelingen - Koninklijke Academie Voor Geneeskunde Van Belgie
|October 11, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effect of Theophylline on Endotoxin and Tumor Necrosis Factor Induced Airway Changes in an in vivo Animal Model.

International archives of allergy and immunology·2021
Same author

[Diffuse interstitial lung disorders in systemic diseases].

Verhandelingen - Koninklijke Academie voor Geneeskunde van Belgie·2004
Same author

Murine models of asthma.

The European respiratory journal·2003
Same author

Dose-related effect of inhaled fluticasone on allergen-induced airway changes in rats.

The European respiratory journal·2002
Same author

Cytokines in asthma.

The European respiratory journal. Supplement·2002
Same author

Clinical applications of assessment of airway inflammation using induced sputum.

The European respiratory journal. Supplement·2002
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Asthma involves airway inflammation and hyperresponsiveness. Chronic airway remodeling significantly impacts bronchial hyperresponsiveness more than acute inflammation.

Area of Science:

  • Pulmonary Medicine
  • Immunology
  • Pathology

Context:

  • Asthma is a chronic inflammatory airway disorder.
  • Bronchial hyperresponsiveness (BHR) is a key feature of asthma.
  • The relationship between inflammation and BHR is not fully understood.

Purpose:

  • To investigate the causal relationship between airway inflammation and BHR in asthma.
  • To analyze the contributions of airway wall compartments to hyperreactivity.
  • To differentiate the roles of acute and chronic inflammation in asthma.

Summary:

  • Asthma involves acute inflammation with eosinophils and Th2 lymphocytes, and chronic inflammation leading to airway remodeling.
  • Airway wall thickening in asthma affects lumen, smooth muscle, and outer compartments.

Related Experiment Videos

  • In vivo models suggest chronic airway remodeling has a greater impact on BHR than acute inflammation.

    • Impact:

    • Understanding airway wall remodeling is crucial for evaluating asthma.
    • Differentiating acute and chronic inflammatory effects clarifies BHR mechanisms.
    • This research informs targeted therapies for asthma management.