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Related Experiment Videos

Severe persistent orf in young goats.

A de la Concha-Bermejillo1, J Guo, Z Zhang

  • 1Department of Veterinary Pathobiology, College of Veterinary Medicine, Texas A&M University, College Station, TX 77843, USA.

Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc
|October 11, 2003
PubMed
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Generalized orf in young Boer goats caused severe skin lesions and systemic illness. This study identified orf virus in skin but not blood, suggesting breed susceptibility factors.

Area of Science:

  • Veterinary Virology
  • Dermatology
  • Immunology

Background:

  • Orf (contagious ecthyma) is a common viral disease in small ruminants.
  • Typically, orf presents as lip and nostril lesions in sheep and goats.
  • Generalized orf cases are less common but can be severe.

Purpose of the Study:

  • To describe a severe, generalized form of orf in goat kids.
  • To investigate clinical, epidemiological, and virological characteristics of these cases.
  • To explore potential breed-specific susceptibility in Boer goats.

Main Methods:

  • Clinical case description of 16 affected goat kids.
  • Serological testing for immunoglobulin concentrations.
  • Orf virus detection via cell culture, electron microscopy, and PCR.

Related Experiment Videos

  • Cross-neutralization assays with orf virus isolates.

    • Main Results:

    • Affected goats exhibited severe, proliferative dermatitis and lymphadenomegaly.
    • Elevated immunoglobulin levels were observed in affected kids.
    • Orf virus was confirmed in skin lesions but not peripheral blood or lymph nodes.
    • Associated conditions included arthritis, pneumonia, and thymic involution.

    Conclusions:

    • This generalized orf presentation in Boer goat kids suggests potential breed-specific susceptibility.
    • Orf virus identification was limited to affected skin tissues.
    • Further research is needed to understand the pathogenesis and breed factors in severe orf cases.