Related Experiment Videos
Peritoneal defense in continuous ambulatory versus continuous cyclic peritoneal dialysis
C W de Fijter1, H A Verbrugh, L P Oe
1Department of Internal Medicine, Free University Hospital, Amsterdam, The Netherlands.
Kidney International
|October 1, 1992
Summary
Continuous cyclic peritoneal dialysis (CCPD) and continuous ambulatory peritoneal dialysis (CAPD) patients show similar peritoneal macrophage function and effluent opsonic activity. Dialysis dwell time significantly impacts these host defense mechanisms in both CCPD and CAPD patients.
Area of Science:
- Nephrology
- Immunology
- Renal Replacement Therapy
Background:
- Peritonitis rates are reportedly lower in continuous cyclic peritoneal dialysis (CCPD) compared to continuous ambulatory peritoneal dialysis (CAPD).
- Previous studies suggest dialysis dwell time influences peritoneal macrophage (PMO) function and effluent opsonic activity.
Purpose of the Study:
- To investigate differences in local host defense between CCPD and CAPD regimens.
- To assess the impact of dwell time on PMO function and effluent opsonic activity in both dialysis modalities.
Main Methods:
- Prospective study comparing eight CCPD patients with eight CAPD patients.
- Peritoneal macrophage phagocytic capacity, chemiluminescence, and effluent opsonic activity were measured after short (4 hr) and long (15 hr) dwell times.
Main Results:
- PMO phagocytic capacity, chemiluminescence, and effluent opsonic activity significantly increased with dwell time in both CAPD and CCPD groups (P < 0.01).
- No significant differences in these host defense parameters were observed between CAPD and CCPD patients when dwell times were equal.
Conclusions:
- Dialysis dwell time, rather than the specific dialysis modality (CCPD vs. CAPD), is a significant factor influencing peritoneal host defense mechanisms.
- These findings suggest that optimizing dwell times may be crucial for enhancing peritoneal defense in patients undergoing either CCPD or CAPD.