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Transcription within a functional human centromere.

Richard Saffery1, Huseyin Sumer, Sara Hassan

  • 1The Murdoch Childrens Research Institute, Royal Children's Hospital, Flemington Road, Melbourne, 3052, Australia.

Molecular Cell
|October 11, 2003
PubMed
Summary
This summary is machine-generated.

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A functional human centromere contains transcriptionally active chromatin, challenging the view of centromeres as transcriptionally silent heterochromatin. This study reveals that centromeric chromatin can be constitutively modified yet permissive to transcription in vivo.

Area of Science:

  • Cell Biology
  • Epigenetics
  • Genetics

Background:

  • Recent studies in yeast and Drosophila suggest a domain-like centromere structure.
  • This structure includes a modified chromatin core and flanking heterochromatin regions.

Purpose of the Study:

  • To analyze a functional human centromere.
  • To define regions of chromosome scaffold/matrix attachment and their relationship with centromeric proteins and heterochromatin.

Main Methods:

  • Analysis of a functional human centromere.
  • Identification of domains for constitutive centromere proteins CENP-A and CENP-H, and heterochromatin protein HP1.
  • Assessment of transcriptional competency within specific centromeric regions.

Main Results:

Related Experiment Videos

  • A region of increased chromosome scaffold/matrix attachment was defined.
  • This region overlaps distinct, nonoverlapping domains of CENP-A, CENP-H, and HP1.
  • Transcriptional competency was observed within the S/MAR-enriched region and CENP-A/CENP-H chromatin.

Conclusions:

  • Functional eukaryotic centromeres possess constitutively modified, nonheterochromatic chromatin.
  • Transcription is permissible within these centromeric chromatin regions.
  • This challenges the traditional view of centromeres as transcriptionally silent.