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Related Experiment Videos

Dynamic cardiomyoplasty acutely impairs left ventricular diastolic function.

W J Corin1, D T George, J D Sink

  • 1Philadelphia Heart Institute, Presbyterian Medical Center, PA 19104.

The Journal of Thoracic and Cardiovascular Surgery
|December 1, 1992
PubMed
Summary

Dynamic cardiomyoplasty using latissimus dorsi muscle wrap in dogs impaired left ventricular diastolic function. Early results suggest this surgical therapy may negatively impact relaxation and increase stiffness, without improving filling rates.

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Area of Science:

  • Cardiovascular Surgery
  • Cardiac Physiology
  • Surgical Innovation

Background:

  • Congestive heart failure presents high mortality and morbidity.
  • Transplantation options are limited by donor heart availability.
  • Dynamic cardiomyoplasty is an investigational surgical therapy for left ventricular dysfunction.

Purpose of the Study:

  • To evaluate the early postoperative effects of dynamic cardiomyoplasty on left ventricular diastolic function.
  • To assess changes in diastolic parameters following latissimus dorsi muscle wrap and stimulation.
  • To determine if synchronous stimulation improves diastolic function in a canine model.

Main Methods:

  • Sonomicrometry and micromanometry were used in seven dogs.
  • Measurements were taken at baseline, after muscle wrap without stimulation, and with synchronous stimulation.

Related Experiment Videos

  • Left ventricular diastolic parameters including pressure, decay rates, stiffness, filling rate, and area were analyzed.

    • Main Results:

    • Latissimus dorsi muscle wrap increased end-diastolic pressure and passive chamber stiffness.
    • The peak rate of diastolic pressure decay decreased, and the constant of pressure decay prolonged.
    • Synchronous stimulation did not improve diastolic filling rate or end-diastolic area; it also prolonged relaxation and increased stiffness.

    Conclusions:

    • Early dynamic cardiomyoplasty in this model prolonged left ventricular relaxation and increased passive stiffness.
    • Synchronous latissimus dorsi muscle stimulation with left ventricular contraction did not enhance diastolic function.
    • The findings suggest that dynamic cardiomyoplasty may impair diastolic function in the early postoperative period.