Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Amylin.

B J Edwards1, J E Morley

  • 1Division of Geriatric Medicine, Saint Louis University, School of Medicine, MO 63104.

Life Sciences
|January 1, 1992
PubMed
Summary
This summary is machine-generated.

Amylin, a pancreatic peptide, may influence aging and Type II diabetes, but its role in hyperglycemia remains debated. This peptide also impacts bone, blood vessels, appetite, and memory.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

High-fidelity scaling relationships for determining dissipative particle dynamics parameters from atomistic molecular dynamics simulations of polymeric liquids.

Scientific reports·2020
Same author

The American Orthopaedic Association's Own the Bone® database: a national quality improvement project for the treatment of bone health in fragility fracture patients.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2018
Same author

Elevated incidence of fractures in women with invasive breast cancer.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2015
Same author

Advancing pharmacovigilance through academic-legal collaboration: the case of gadolinium-based contrast agents and nephrogenic systemic fibrosis-a Research on Adverse Drug Events and Reports (RADAR) report.

The British journal of radiology·2014
Same author

Reporting of serious adverse events during cancer clinical trials to the institutional review board: an evaluation by the research on adverse drug events and reports (RADAR) project.

Journal of clinical pharmacology·2013
Same author

Development of an electronic medical record based intervention to improve medical care of osteoporosis.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2012
Same journal

Corrigendum to "Adipose stem cells-derived microvesicles and chicken egg-derived exosomes attenuate cardiac ischemia/reperfusion injury through AKT/ERK/Nrf2/HO-1 axis to inhibit apoptosis and inflammation and restore autophagy" [Life Sci. 395 (2026) 124364].

Life sciences·2026
Same journal

MAGED1 stabilizes NEUROD1 to promote Per3 expression in the pineal gland.

Life sciences·2026
Same journal

TNF-centered network pharmacology and molecular modeling of selected Andrographis paniculata compounds in hypertension.

Life sciences·2026
Same journal

Retraction notice to "Beneficial effect of Calculus Bovis Sativus on 17α-ethynylestradiol-induced cholestasis in the rat" [Life Sci. 113 (2014) 22-30].

Life sciences·2026
Same journal

Soluble PD-1 drives renal fibrosis in CKD by disrupting immune homeostasis: Therapeutic mitigation via a targeted sPD-1 sequestration strategy.

Life sciences·2026
Same journal

METTL1 promotes hepatic steatosis by mediating m<sup>7</sup>G modification of ALOX15B mRNA.

Life sciences·2026
See all related articles

Area of Science:

  • Endocrinology
  • Molecular Biology
  • Gerontology

Background:

  • Amylin is a 37 amino-acid peptide secreted by pancreatic islet cells.
  • It shares sequence homology with calcitonin gene-related peptide.
  • Amylin can form amyloid deposits within pancreatic islet cells.

Purpose of the Study:

  • To review the physiological effects of amylin.
  • To explore the potential role of amylin in aging and Type II diabetes mellitus.
  • To postulate a role for amylin in age-related changes.

Main Methods:

  • Literature review of amylin's physiological effects.
  • Analysis of amylin's sequence homology and deposition.
  • Evaluation of studies investigating amylin's impact on glucose metabolism and other functions.

Related Experiment Videos

Main Results:

  • Amylin secretion is stimulated similarly to insulin.
  • Amylin may counteract insulin's effects, potentially increasing hepatic glucose output and decreasing insulin sensitivity.
  • Supraphysiological doses are often required to observe these effects, making its role in hyperglycemia controversial.
  • Amylin also exhibits osteoclastic inhibition, vasodilation, anorectic effects, and enhanced memory retention.

Conclusions:

  • The role of amylin in the hyperglycemia associated with aging and Type II diabetes mellitus is currently controversial.
  • Amylin's diverse physiological effects suggest a broader role in age-related changes beyond glucose metabolism.
  • Further research is needed to elucidate amylin's precise function and therapeutic potential.