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Autoantibodies to nucleolin cross-react with histone H1 in systemic lupus erythematosus
W N Jarjour1, S Minota, R A Roubey
1Thurston Arthritis Research Center, University of North Carolina, Chapel Hill 27599-7280.
Molecular Biology Reports
|September 1, 1992
Abstract:
IgM autoantibodies to nucleolin and histone H1 are strongly associated in the serum of patients with systemic lupus erythematosus. IgM eluted from immobilized nucleolin specifically stained histone H1 blotted to nitrocellulose; conversely, IgM eluates prepared from immobilized histone H1 stained nucleolin blots. We conclude that the linkage of anti-nucleolin and anti-histone H1 autoantibodies in SLE is due, at least in part, to immunologic cross-reactivity between these two autoantigens, which share certain similar structural features.