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Related Experiment Videos

Membrane bioreactors: Engineering aspects.

H N Chang1

  • 1Department of Chemical Engineering. Korea Advanced Institute of Science and Technology, PO Box 131 Dongdaemun, Seoul, Korea.

Biotechnology Advances
|January 1, 1987
PubMed
Summary
This summary is machine-generated.

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Membrane bioreactors offer unique in-situ separation for enzyme reactions and cell cultures. Their protective environment benefits animal and plant cell growth, enhancing process efficiency.

Area of Science:

  • Biotechnology and biochemical engineering
  • Cell culture technology
  • Bioprocess engineering

Background:

  • Traditional immobilized cell reactors lack in-situ separation capabilities.
  • Membrane bioreactors (MBRs) offer integrated separation, enhancing process control and efficiency.
  • Specific applications, such as enzyme catalysis and cell culture, can significantly benefit from MBR technology.

Purpose of the Study:

  • To highlight the advantages of membrane bioreactors (MBRs) in various bioprocesses.
  • To discuss the suitability of MBRs for enzyme reactions and cell culture.
  • To identify specific MBR configurations for different biological applications.

Main Methods:

  • Review of MBR capabilities for in-situ separation.
  • Analysis of MBR suitability for enzyme-catalyzed reactions involving cofactors and macromolecule hydrolysis.

Related Experiment Videos

  • Evaluation of MBR configurations for anaerobic and aerobic cell cultures.
  • Assessment of MBRs for animal and plant cell culture.

    • Main Results:

    • MBRs provide essential in-situ separation, a key advantage over other immobilized cell systems.
    • Enzyme reactions, particularly those using cofactors or hydrolyzing macromolecules, are well-suited for MBRs.
    • Anaerobic cell culture is efficient in membrane cell recycle systems, while aerobic cultures perform well in dual hollow fiber reactors.
    • Animal and plant cells show improved success rates in MBRs due to the protective environment and low oxygen demand.

    Conclusions:

    • Membrane bioreactors are versatile systems with significant advantages for bioprocessing.
    • The in-situ separation capability of MBRs enables efficient handling of sensitive reactions and cultures.
    • Specific MBR designs can be optimized for diverse applications, including enzyme catalysis and the culture of delicate animal and plant cells.