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Magnetic separation in biotechnology.
E H Dunlop1, W A Feiler, M J Mattione
1Department of Chemical Engineering, Washington University, St. Louis, Missouri 63130, USA.
Biotechnology Advances
|January 1, 1984
Summary
New magnetic labeling methods enhance magnetic separation for biotechnology. This review covers recent techniques and their potential for large-scale biotechnical applications.
Area of Science:
- Biotechnology
- Biophysics
- Materials Science
Background:
- Magnetic separation is a powerful technique for isolating biological entities.
- Advancements in magnetic labeling have broadened its applicability.
- High gradient magnetic separation (HGMS) is particularly relevant for biotechnical applications.
Purpose of the Study:
- To review the fundamental magnetic principles underlying magnetic separation techniques.
- To present recent developments in magnetic labeling for cells and microspheres.
- To illustrate the potential of these techniques in biotechnical applications.
Main Methods:
- Review of magnetic principles relevant to separation.
- Compilation and analysis of recent magnetic labeling techniques (past three years).
- Presentation of case studies and examples of large-scale industrial operations.
Main Results:
- New magnetic labeling techniques have significantly extended the utility of magnetic separation.
- Specific examples demonstrate successful application in biotechnical contexts.
- Industrial applications showcase the scalability and potential of these methods.
Conclusions:
- Magnetic separation, enhanced by novel labeling techniques, offers significant potential for biotechnology.
- The reviewed methods provide a foundation for further innovation in biological separations.
- Large-scale operations in other industries highlight the future prospects for biotechnical magnetic separation.