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Practolol and deafness.

R F Jones, V T Hammond, D Wright

    The Journal of Laryngology and Otology
    |November 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Prolonged use of practolol (Eraldin), a beta-blocking agent, can cause side effects including deafness. Hearing loss may be arrested by discontinuing the drug, and otologists should report suspicious cases.

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    Area of Science:

    • Ophthalmology
    • Ototoxicology
    • Pharmacology

    Background:

    • Practolol (Eraldin) is a beta-blocking agent used for cardiovascular conditions.
    • Long-term administration of practolol has been associated with various adverse effects.
    • Ocular symptoms and skin rashes are known side effects of practolol.

    Observation:

    • This report details ten cases of deafness linked to practolol use.
    • In most cases, deafness manifested months after the onset of skin and eye lesions.
    • The temporal relationship suggests a potential drug-induced ototoxicity.

    Findings:

    • Practolol-induced deafness is a significant adverse effect.
    • The progression of hearing loss may be halted upon cessation of the drug.

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  • Early identification and withdrawal are crucial for managing this side effect.

    • Implications:

    • Otolaryngologists should be vigilant for practolol-associated hearing loss.
    • Reporting suspected cases to regulatory bodies aids in pharmacovigilance.
    • Understanding drug-induced ototoxicity is vital for patient safety and drug monitoring.