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Solid state fermentation reactors: from lab scale to pilot plant.

A Durand1, R Renaud, S Almanza

  • 1Plate-forme de Prédéveloppement en Biotechnologie, Institut National de la Recherche Agronomique (INRA), Dijon, France.

Biotechnology Advances
|January 1, 1993
PubMed
Summary
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Researchers developed novel bioreactors for deep-layer solid-state fermentation (SSF), scaling from lab to pilot plants. These advanced SSF reactors feature forced aeration and controlled environmental conditions for optimized microbial processes.

Area of Science:

  • Biotechnology
  • Biochemical Engineering
  • Microbial Fermentation

Background:

  • Solid-state fermentation (SSF) is widely studied, yet reactor design and scale-up remain under-explored areas.
  • Scaling up SSF processes presents unique challenges due to the heterogeneous nature of the substrate and microbial growth.

Purpose of the Study:

  • To present the development and application of novel bioreactors for deep-layer solid-state fermentation.
  • To demonstrate a consistent technology, reactor design, and flowsheet for scaling SSF from laboratory to pilot plant.

Main Methods:

  • Development of SSF reactors with forced aeration and optional agitation, enabling deep-layer fermentation up to 1 meter.
  • Implementation of a monitoring device for precise regulation of temperature and water content within the culture.

Related Experiment Videos

  • Consistent application of technology, reactor design, and flowsheet across scales.

    • Main Results:

    • Successful scale-up of SSF processes from laboratory to pilot plant scale using a unified approach.
    • Demonstration of controlled fermentation conditions with deep-layer capabilities (up to 1 m).
    • Effective monitoring and regulation of critical parameters like temperature and water content.

    Conclusions:

    • The developed SSF reactor technology and design are suitable for scaling up fermentation processes.
    • The ability to control environmental parameters and achieve deep-layer fermentation is crucial for efficient SSF.
    • This work addresses the gap in SSF reactor design and scale-up, offering a viable solution for industrial applications.