Anticoccidial efficacy and chicken toleration of potent new polyether ionophores. 1. The septamycin relative CP-82,009
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A P Ricketts1, J P Dirlam, J E Shively
1Central Research Division, Pfizer Inc, Groton, Connecticut 06340.
Abstract:
The anticoccidial activity of the ionophore CP-82,009 against laboratory isolates of four major species of poultry Eimeria was investigated. Parameters of anticoccidial efficacy that were evaluated were control of lesions and weight suppression. At 4 and 5 ppm, CP-82,009 demonstrated broad-spectrum anticoccidial efficacy in battery trials that was equivalent to reference commercial ionophores. When CP-82,009 was fed to uninfected broiler chickens at efficacious dose levels, growth rate and feed efficiency were found to be equivalent to commercial agents over a 21-day period in batteries and over a 49-day period in floor pens. From the present studies, it appears that CP-82,009 is an efficacious anticoccidial that is well tolerated by chickens, and that it ranks among the most potent anticoccidial ionophores described to date.
Insights
The anticoccidial drug CP-82,009 effectively controls Eimeria in poultry, showing broad-spectrum efficacy and no adverse effects on growth or feed efficiency in chickens.
Area of Science:
- Veterinary Parasitology
- Poultry Science
- Drug Discovery
Background:
- Coccidiosis is a significant parasitic disease in poultry, caused by Eimeria species.
- Ionophores are commonly used to control coccidiosis in chickens.
- There is a continuous need for novel anticoccidial agents with high efficacy and safety.
Purpose of the Study:
- To evaluate the anticoccidial activity of the novel ionophore CP-82,009.
- To assess the efficacy of CP-82,009 against major poultry Eimeria species.
- To determine the safety and impact of CP-82,009 on broiler chicken growth and feed efficiency.
Main Methods:
- Laboratory battery trials were conducted to assess anticoccidial efficacy.
- Efficacy was measured by lesion control and weight suppression.
- Growth rate and feed efficiency were evaluated in uninfected broiler chickens over 21-day (battery) and 49-day (floor pen) periods.
Main Results:
- CP-82,009 demonstrated broad-spectrum anticoccidial efficacy at 4 and 5 ppm, comparable to commercial ionophores.
- The drug effectively controlled lesions and weight suppression caused by Eimeria.
- No negative impact on growth rate or feed efficiency was observed in chickens treated with CP-82,009.
Conclusions:
- CP-82,009 is a highly efficacious anticoccidial agent against poultry Eimeria.
- The compound is well-tolerated by broiler chickens at efficacious doses.
- CP-82,009 represents a potent new option among anticoccidial ionophores.