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Related Experiment Videos

Rheology of filamentous fermentations.

E Olsvik1, B Kristiansen

  • 1Strathclyde Fermentation Centre, University of Strathclyde, Glasgow, UK.

Biotechnology Advances
|January 1, 1994
PubMed
Summary

Bioreactor performance depends on broth rheology, influenced by biomass morphology. Understanding rheology-morphology links requires integrated studies beyond simple biomass concentration for better filamentous fermentation control.

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Correlation of Aspergillus niger broth rheological properties with biomass concentration and the shape of mycelial aggregates.

Biotechnology and bioengineering·1993

Area of Science:

  • Biochemical Engineering
  • Rheology
  • Bioprocess Engineering

Background:

  • Bioreactor performance is significantly impacted by the rheological properties of filamentous fermentation broths.
  • Broth rheology is primarily dictated by biomass concentration, growth rate, and morphology, including hyphal geometry and interactions.

Purpose of the Study:

  • To emphasize the limitations of viscosity-biomass correlations and highlight the need for integrated rheological and morphological studies.
  • To advocate for the use of on-line measurement equipment for dynamic analysis of morphology and rheology in filamentous fermentations.

Main Methods:

  • Discusses the limitations of off-line rheological measurements due to sample treatment issues.
  • Highlights the availability but underutilization of on-line equipment for dynamic morphology and rheology measurements.
  • Compares current simulation methods using polymer solutions with the need for studies on non-homogeneous fermentation fluids.

Main Results:

  • Correlations based solely on biomass concentration are insufficient for describing broth rheology.
  • Integrated rheological and morphological studies are crucial for a deeper understanding.
  • On-line measurement technologies offer potential for improved process monitoring and control.

Conclusions:

  • Effective control of mycelial fermentation rheology is challenging due to numerous influencing factors.
  • Simulations using polymer solutions lack the impact of active biomass on mass transfer and flow.
  • Further research on non-homogeneous fermentation fluids is essential for developing accurate predictive correlations.

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