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Updated: Aug 30, 2026

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Published on: May 31, 2022
Endothelial nitric oxide synthase: a determinant of TNFalpha production by human monocytes/macrophages
Heiko Mühl1, Josef Pfeilschifter
1Pharmazentrum frankfurt, Klinikum der Johann Wolfgang Goethe-Universität Frankfurt am Main, Frankfurt am Main, Germany. H.Muehl@em.uni-frankfurt.de
Abstract:
Until recently endothelial nitric oxide synthase (eNOS) has been associated exclusively with physiological functions, particularly in the cardiovascular system. However, increasing evidence has been accumulated that supports the concept for a role of eNOS in pathophysiology. In particular, detection of eNOS protein and activity in human monocytes/macrophages suggest an immunomodulatory role of this enzyme. Here, we review data that promote the hypothesis that by enhancing TNFalpha production, eNOS activity should be regarded as a novel pro-inflammatory parameter in human monocytes/macrophages.
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