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Acute fatal poisoning with cyamemazine.
V Alunni-Perret1, P Ohayon, H P Duval
1Laboratoire de Médecine Légale et Anthropologie Medico-Légale, Faculte de Médecine, Avenue de Valombrose, 06107 Nice Cedex 2, France. alunni-perret.v@chu-nice.fr
Forensic Science International
|October 11, 2003
Summary
Fatal poisoning with cyamemazine (1800 ng/ml) was identified in post-mortem blood. Chronic use was confirmed by hair analysis, but combined drug toxicity cannot be ruled out.
Area of Science:
- Forensic Toxicology
- Pharmacology
Background:
- Cyamemazine is an antipsychotic medication.
- Limited data exists on therapeutic and toxic levels in overdose cases.
Observation:
- A fatal poisoning case involving cyamemazine is presented.
- Cyamemazine was detected in post-mortem blood at 1800 ng/ml.
- Chronic cyamemazine use was indicated by hair analysis.
Findings:
- A specific gas chromatography/mass spectrometry method identified cyamemazine.
- Bromazepam and trimeprazine were also detected in the blood.
- The 1800 ng/ml blood concentration is considered guidance for fatal cyamemazine poisoning, acknowledging potential combined drug toxicity.
Implications:
- This case provides valuable data on cyamemazine toxicity levels.
- Highlights the importance of comprehensive toxicological analysis in fatal cases.
- Contributes to understanding cyamemazine's role in drug-related deaths.