Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A proposed inhalation reference concentration for methanol.

Thomas B Starr1, John L Festa

  • 1TBS Associates, 7500 Rainwater Road, Raleigh, NC 27615-3700, USA. tbstarr@mindspring.com

Regulatory Toxicology and Pharmacology : RTP
|October 11, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Review of Stable Isotope Labeling and Mass Spectrometry Methods to Distinguish Exogenous from Endogenous DNA Adducts and Improve Dose-Response Assessments.

Chemical research in toxicology·2021
Same author

A Review of Wood Dust Longitudinal Health Studies: Implications for an Occupational Limit Value.

Dose-response : a publication of International Hormesis Society·2019
Same author

The bottom-up approach to bounding potential low-dose cancer risks from formaldehyde: An update.

Regulatory toxicology and pharmacology : RTP·2016
Same author

Formation, Accumulation, and Hydrolysis of Endogenous and Exogenous Formaldehyde-Induced DNA Damage.

Toxicological sciences : an official journal of the Society of Toxicology·2015
Same author

Response to Crump et al.

Regulatory toxicology and pharmacology : RTP·2014
Same author

Vanadium pentoxide: risk assessment implications of a treatment- but not dose-related tumorigenic response in B6C3F1 mice.

Regulatory toxicology and pharmacology : RTP·2014
Same journal

The NTP Chronic Inhalation Study Does Not Support an Inherent Lung Cancer Hazard of Talc: Implications of Lung Particle Overload and Maximum Tolerated Dose.

Regulatory toxicology and pharmacology : RTP·2026
Same journal

Consideration of Carcinogenicity and Mode of Action Information by an Independent Expert Panel to Support Derivation of No-Significant-Risk-Level Values for Vinyl Acetate Monomer.

Regulatory toxicology and pharmacology : RTP·2026
Same journal

Which carcinogenicity study should I use? Automated identification of reliable studies.

Regulatory toxicology and pharmacology : RTP·2026
Same journal

Adoption of artificial intelligence in drug review across the lifecycle: Transformation of regulatory decision-making.

Regulatory toxicology and pharmacology : RTP·2026
Same journal

Cardiovascular outcomes following intrauterine and lactational exposure to cyantraniliprole in male Wistar rats.

Regulatory toxicology and pharmacology : RTP·2026
Same journal

Pesticide residue and mycotoxin occurrence in apples and their impact on human health in Morocco.

Regulatory toxicology and pharmacology : RTP·2026
See all related articles

This study establishes a safe inhalation Reference Concentration (RfC) for methanol, a common industrial chemical. The findings provide crucial data for protecting human health from methanol exposure.

Area of Science:

  • Environmental Health
  • Toxicology
  • Chemical Safety

Background:

  • Methanol is a high-production volume chemical with widespread industrial and commercial applications.
  • Assessing potential human health risks from methanol inhalation is critical due to its prevalence.
  • Developing a biologically based Reference Concentration (RfC) is essential for regulatory and safety guidelines.

Purpose of the Study:

  • To derive an inhalation Reference Concentration (RfC) for methanol using a biologically based approach.
  • To identify the most sensitive toxicological endpoint for risk assessment in humans.
  • To establish safe exposure limits for methanol in occupational and environmental settings.

Main Methods:

  • Applied Benchmark Dose (BMD) methodology to cervical rib malformation data in CD-1 mice.

Related Experiment Videos

  • Utilized blood methanol concentration as the dose metric.
  • Employed a physiologically based pharmacokinetic (PBPK) model to convert blood levels to inhalation concentrations.

    • Main Results:

    • The maximum likelihood estimate for blood methanol increment causing a 10% extra risk of malformations was 215.4 mg/L.
    • A Reference Increment in blood methanol was calculated using uncertainty factors for interspecies and interindividual variation.
    • The estimated inhalation RfC for methanol was 298 mg/m3, with a 95% lower confidence bound of 135 mg/m3.

    Conclusions:

    • The derived inhalation RfC provides a scientifically sound basis for protecting public health from methanol exposure.
    • The study highlights the importance of sensitive toxicological endpoints and pharmacokinetic modeling in risk assessment.
    • This research contributes to the safe use of methanol as an industrial chemical and alternative fuel.