Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Autoantigenicity of nucleolar complexes.

Tim J M Welting1, Reinout Raijmakers, Ger J M Pruijn

  • 1Department of Biochemistry 161, Nijmegen Centre for Molecular Life Sciences, University of Nijmegen, P.O. Box 9101, NL-6500 HB Nijmegen, The Netherlands.

Autoimmunity Reviews
|October 11, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

International expert consensus recommendations on standardised nomenclature of SSA/Ro (TROVE2/Ro60 and TRIM21/Ro52) autoantibodies in autoimmune diseases.

Annals of the rheumatic diseases·2026
Same author

Peptide p[63-82] induces transcriptomic alterations associated with processes involved in cartilage repair in osteoarthritic human chondrocytes.

Connective tissue research·2026
Same author

A New Immunofluorescence Assay Allows the Sensitive Detection of Anti-Cytosolic 5'-Nucleotidase 1A Autoantibodies.

European journal of immunology·2026
Same author

In vivo evaluation of the antibacterial properties of a poly-ε-lysine and hyaluronic acid coated intramedullary implant in a New Zealand White rabbit model.

PloS one·2026
Same author

Ribosome heterogeneity and specialization in musculoskeletal physiology and pathology.

JBMR plus·2026
Same author

In vitro assessment of antibacterial and biocompatibility properties of a poly-ε-lysine and hyaluronic acid contact-killing coating to prevent prosthetic joint infection.

PloS one·2026
Same journal

Decoding gut microbiome alterations in celiac disease: Implications for pathogenesis and treatment.

Autoimmunity reviews·2026
Same journal

Rethinking immunosuppression in limited cutaneous systemic sclerosis. The lcSSc conundrum; pros and cons for a timely immunosuppressive treatment.

Autoimmunity reviews·2026
Same journal

Kidney failure in patients with ANCA-associated vasculitis: A systematic review of outcomes.

Autoimmunity reviews·2026
Same journal

The role of antimicrobial peptides in rheumatoid arthritis: From mucosal predisposition to chronic synovitis.

Autoimmunity reviews·2026
Same journal

The role of short-chain fatty acids as key mediators of gut microbiota - host crosstalk in thyroid diseases.

Autoimmunity reviews·2026
Same journal

Intermittent hydrarthrosis (periodic synoviosis): A narrative review.

Autoimmunity reviews·2026
See all related articles

Autoantibodies to nucleolar autoantigens (ANoA) are key biomarkers in systemic sclerosis (SSc). This review details the molecular composition, function, and autoantigenicity of these critical nucleolar targets in SSc patients.

Area of Science:

  • Immunology
  • Molecular Biology
  • Rheumatology

Background:

  • Autoantibodies targeting nucleolar autoantigens (ANoA) are prevalent in systemic sclerosis (SSc) and SSc overlap syndromes.
  • Recent advances have identified numerous nucleolar components, enabling detailed analysis of nucleolar autoantigens.

Purpose of the Study:

  • To review the molecular composition of major autoantigenic nucleolar complexes.
  • To provide insights into the functions of these nucleolar components.
  • To summarize current data on the autoantigenicity of nucleolar targets in SSc.

Main Methods:

  • Literature review of studies on nucleolar autoantigens.
  • Analysis of molecular composition and functional data.
  • Synthesis of autoantigenicity information.

Related Experiment Videos

Main Results:

  • Identification of major autoantigenic nucleolar complexes.
  • Elucidation of the functions of key nucleolar autoantigens.
  • Comprehensive summary of autoantigenicity data.

Conclusions:

  • ANoA are important diagnostic and potentially prognostic markers in SSc.
  • Understanding nucleolar autoantigens deepens insights into SSc pathogenesis.
  • Further research into nucleolar autoantigens may reveal therapeutic targets.