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Compliance therapy: a randomised controlled trial in schizophrenia
Colin O'Donnell1, Gary Donohoe, Louise Sharkey
1Stanley Research Unit, Department of Adult Psychiatry, Cluain Mhuire Service, Newtownpark Avenue, Dublin, Republic of Ireland.
BMJ (Clinical Research Ed.)
|October 11, 2003
Summary
Compliance therapy did not significantly improve medication adherence in schizophrenia patients compared to non-specific counseling. Patient attitudes toward treatment at the start of the study predicted adherence one year later.
Area of Science:
- Psychiatry
- Clinical Psychology
- Pharmacology
Background:
- Medication adherence is crucial for managing schizophrenia.
- Compliance therapy is a potential intervention to improve treatment adherence.
Purpose of the Study:
- To evaluate the efficacy of compliance therapy in enhancing medication adherence for schizophrenia patients.
- To assess the impact of compliance therapy on various clinical outcomes.
Main Methods:
- A randomized controlled trial was conducted.
- 56 schizophrenia patients participated in 5 sessions of either compliance therapy or non-specific counseling.
- Outcomes measured included adherence, symptomatology, insight, quality of life, and rehospitalization rates.
Main Results:
- Compliance therapy showed no significant advantage over non-specific therapy in improving medication adherence at one year.
- No significant differences were observed in secondary outcomes such as symptomatology, attitudes to treatment, insight, or quality of life.
- Baseline attitudes towards treatment predicted one-year adherence.
Conclusions:
- Compliance therapy may not offer substantial benefits for patients with schizophrenia.
- Assessing patient attitudes toward treatment at baseline could be a valuable tool for predicting adherence.