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Related Experiment Video

Updated: Jun 25, 2026

Measuring Left Ventricular Pressure in Late Embryonic and Neonatal Mice
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Measuring Left Ventricular Pressure in Late Embryonic and Neonatal Mice

Published on: February 23, 2012

Developmental changes in ventricular diastolic function correlate with changes in ventricular myoarchitecture in

Takahiro Ishiwata1, Makoto Nakazawa, William T Pu

  • 1Cardiovascular Division, Beth Israel Deaconess Medical Center, Boston, Mass 02215, USA.

Circulation Research
|October 11, 2003
PubMed
Summary

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Investigating embryonic cardiac function, this study reveals compact myocardium development is crucial for ventricular distensibility. Abnormalities in FOG-2 null embryos suggest impaired diastolic function causes embryonic lethality.

Area of Science:

  • Cardiovascular Biology
  • Developmental Biology
  • Cardiac Physiology

Background:

  • Congenital heart disease arises from genetic and epigenetic factors affecting cardiac development.
  • Evaluating embryonic diastolic function is critical for understanding cardiac performance and disease pathogenesis.

Purpose of the Study:

  • To investigate developmental changes in ventricular diastolic function in mouse embryos.
  • To establish methods for assessing embryonic cardiac performance.
  • To analyze the role of FOG-2 in embryonic cardiac development.

Main Methods:

  • Histological measurements of ventricular myoarchitecture.
  • Doppler assessment of ventricular inflow velocities (E and A waves).
  • Direct measurement of ventricular pressure (-dP/dt).

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Echocardiographic Characterization of Left Ventricular Structure, Function, and Coronary Flow in Neonate Mice
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Echocardiographic Characterization of Left Ventricular Structure, Function, and Coronary Flow in Neonate Mice

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Related Experiment Videos

Last Updated: Jun 25, 2026

Measuring Left Ventricular Pressure in Late Embryonic and Neonatal Mice
08:15

Measuring Left Ventricular Pressure in Late Embryonic and Neonatal Mice

Published on: February 23, 2012

Echocardiographic Measurement of Right Ventricular Diastolic Parameters in Mouse
06:04

Echocardiographic Measurement of Right Ventricular Diastolic Parameters in Mouse

Published on: April 27, 2019

Echocardiographic Characterization of Left Ventricular Structure, Function, and Coronary Flow in Neonate Mice
07:55

Echocardiographic Characterization of Left Ventricular Structure, Function, and Coronary Flow in Neonate Mice

Published on: April 7, 2022

Main Results:

  • Peak A wave velocity correlated with trabecular myocardium area in both ventricles.
  • Peak E wave velocity exponentially correlated with compact myocardium area in both ventricles.
  • FOG-2 null embryos exhibited impaired diastolic function, characterized by thin compact myocardium, higher end-diastolic pressure (EDP), and altered E/A ratio, leading to embryonic lethality.

Conclusions:

  • Compact myocardium development is a key regulator of ventricular distensibility during embryogenesis.
  • Impaired ventricular diastolic function is a potential cause of embryonic lethality in FOG-2 null mice.
  • This study provides a foundation for investigating embryonic cardiac function in genetically modified models.