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Related Experiment Videos

Flared polyurethane-covered self-expandable nitinol stent for malignant biliary obstruction.

Young-Min Han1, Gong-Yong Jin, Seung-Ok Lee

  • 1Department of Radiology, Chonbuk National University Medical School, 634-18, Keumam-Dong, Chonju, 560-182, South Korea. ymhan@chonbuk.ac.kr

Journal of Vascular and Interventional Radiology : JVIR
|October 11, 2003
PubMed
Summary

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This study shows flared polyurethane-covered nitinol stents are effective for malignant biliary obstruction, achieving good drainage and patency. While safe and non-migrating, tumor ingrowth requires further investigation in larger patient groups.

Area of Science:

  • Gastroenterology
  • Interventional Radiology
  • Biomedical Engineering

Background:

  • Malignant biliary obstruction poses significant challenges in patient management.
  • Nitinol stents offer promising properties for biliary interventions.

Purpose of the Study:

  • To assess the technical efficacy and safety of flared polyurethane-covered nitinol stents for malignant biliary obstruction.
  • To evaluate clinical efficacy through stent patency and patient survival rates.

Main Methods:

  • 13 patients with malignant common bile duct strictures received flared polyurethane-covered nitinol stents.
  • Kaplan-Meier analysis was used for survival and patency rates.
  • Follow-up included bilirubin and serum amylase/lipase levels.

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Main Results:

  • Successful stent placement in all patients with 0% 30-day mortality.
  • 77% achieved adequate palliative drainage; 48% stent patency at 50 weeks.
  • No migration occurred, but 23% experienced stent occlusion; bilirubin levels significantly decreased post-procedure.

Conclusions:

  • Flared polyurethane-covered nitinol stents are feasible and effective for biliary drainage in malignant obstruction.
  • Stents demonstrated no migration, but tumor ingrowth into the flared portion was observed.
  • Larger studies are needed to confirm long-term efficacy and address tumor ingrowth.