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Related Experiment Videos

Biological variation of the leukocyte differential count quantities.

D Dot1, J Miró, X Fuentes-Arderiu

  • 1Laboratori d'Anàlisis Clíniques, Hospital de Viladecans, Spain.

Scandinavian Journal of Clinical and Laboratory Investigation
|November 1, 1992
PubMed
Summary

This study quantifies biological variation in leukocyte counts and fractions in healthy adults over one year. Findings reveal sex-based differences in leukocyte and neutrophil variations, crucial for interpreting clinical laboratory results.

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Area of Science:

  • Hematology
  • Clinical Chemistry
  • Biological Variation Analysis

Background:

  • Understanding biological variation in blood cell counts is essential for accurate clinical interpretation.
  • Previous studies have indicated potential sex-based differences in hematological parameters.

Purpose of the Study:

  • To estimate the within-subject biological variation of leukocyte concentrations and number fractions over a one-year period.
  • To identify sex-specific differences in these variations.
  • To calculate key performance indicators for laboratory testing, including the index of individuality and critical difference.

Main Methods:

  • A longitudinal study involving 19 women and 20 men, apparently healthy volunteers.
  • Blood samples analyzed over one year using a Toa E-5000 haematological analyser.

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  • Medians of within-subject biological coefficients of variation calculated for various leukocyte types and fractions, stratified by sex.

    • Main Results:

    • Median within-subject biological variation for leukocyte concentration ranged from 9.4% (men) to 26.9% (women for neutrophils).
    • Significant sex differences observed in leukocyte and neutrophil concentration variations.
    • Number fraction variations showed less pronounced sex differences, with lymphocytes at 0% (men) and 7.2% (women).

    Conclusions:

    • Established reference ranges for biological variation in leukocyte parameters, highlighting sex-specific differences.
    • Provided data for calculating the index of individuality and critical difference, aiding in the interpretation of changes in leukocyte counts.
    • Emphasized the importance of considering biological variation and sex in hematological testing for robust clinical decision-making.