Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Intercellular adhesion molecule-1: a protective haplotype against multiple sclerosis.

I Cournu-Rebeix1, E Génin, G Lesca

  • 1Laboratoire des affections de la myéline et des canaux ioniques musculaires-INSERM U546, Faculté de Médecine Pitié-Salpêtrière, Paris, France.

Genes and Immunity
|October 11, 2003
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cross-cultural adaptation and clinical validation of the Spanish version of the Simplified Evaluation of Consciousness Disorder (SECONDs).

Neurologia·2026
Same author

Guidelines: Basic principles of pain management in acquired brain injury. Recommendations of the Spanish Society of Neurorehabilitation.

Neurologia·2025
Same author

Guideline: Neurorehabilitation in patients with disorder of consciousness. Recommendations from the Spanish Society of Neurorehabilitation.

Neurologia·2025
Same author

Guidelines: basic principles of neurorehabilitation for patients with acquired brain injury. Recommendations of the Spanish Society of Neurorehabilitation.

Neurologia·2023
Same author

[Effectiveness, adherence and usability of a teleneurorehabilitation programme to ensure continuity of care for patients with acquired brain injury during the COVID-19 pandemic].

Revista de neurologia·2021
Same author

Simultaneous determination of 8 beta-lactams and linezolid by an ultra-performance liquid chromatography method with UV detection and cross-validation with a commercial immunoassay for the quantification of linezolid.

Talanta·2020

Genes for intercellular adhesion molecule-1 (ICAM-1) receptors do not affect multiple sclerosis (MS) risk. However, ICAM-1 itself modestly influences MS susceptibility, with a rare haplotype potentially offering protection.

Area of Science:

  • Neuroimmunology
  • Genetics

Background:

  • Intercellular adhesion molecule-1 (ICAM-1) and its receptors are crucial for inflammatory cell migration across the blood-brain barrier.
  • This process is an early event in multiple sclerosis (MS), leading to central nervous system demyelination.

Purpose of the Study:

  • To investigate the genetic influence of ICAM-1 and its receptor genes on MS susceptibility and severity.
  • To identify potential genetic markers associated with MS risk.

Main Methods:

  • A genetic linkage and association study was conducted.
  • Utilized 439 French case-parent MS families with detailed HLA and severity data.

Main Results:

  • Genes encoding ICAM-1 receptors showed no impact on MS susceptibility or severity.

Related Experiment Videos

  • ICAM-1 demonstrated a significant, albeit modest, effect on genetic susceptibility to MS, independent of HLA and disease severity.
  • A novel, rare ICAM-1 haplotype (K469/R241) was identified, which was never transmitted to patients, suggesting a protective role.

    • Conclusions:

    • ICAM-1 receptor genes are not major determinants of MS risk.
    • ICAM-1 plays a role in MS genetic susceptibility.
    • The identified rare ICAM-1 haplotype may confer protection against MS in the studied population.