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The growing teratoma syndrome
Katherine Nimkin1, Punita Gupta, Roy McCauley
1Department of Radiology, The Floating Hospital for Children, Boston, MA, USA. knimkin@partners.org
Pediatric Radiology
|October 11, 2003
Summary
Growing teratoma syndrome involves mature teratoma growth after chemotherapy for germ-cell tumors, often with normal tumor markers. This case highlights the syndrome in an immature ovarian teratoma in a young girl.
Area of Science:
- Gynecologic Oncology
- Pediatric Oncology
- Pathology
Background:
- Malignant nonseminomatous germ-cell tumors (GCTs) are rare in pediatric patients.
- Chemotherapy is a primary treatment modality for GCTs.
- Growing teratoma syndrome (GTS) is a recognized post-chemotherapy complication.
Observation:
- A 12-year-old girl presented with an immature ovarian teratoma.
- Following chemotherapy, enlarging masses were noted.
- Serum tumor markers normalized, inconsistent with progressive malignancy.
Findings:
- The enlarging masses represented mature teratoma, consistent with Growing Teratoma Syndrome.
- This is an unusual presentation of GTS originating from an immature teratoma.
- Clinical and imaging findings were crucial for diagnosis.
Implications:
- Accurate diagnosis of GTS is vital to prevent misinterpretation as recurrent malignancy.
- Understanding GTS in pediatric ovarian tumors is important for appropriate management.
- This case expands the known spectrum of GTS presentations.