Related Experiment Video
Updated: Aug 8, 2026

A Simple and Efficient Method to Detect Nuclear Factor Activation in Human Neutrophils by Flow Cytometry
Published on: April 9, 2013
Nuclear factor-kappaB activation in endothelium by Chlamydia pneumoniae without active infection
Jefferson T Baer1, Tracey V Du Laney, Priscilla B Wyrick
1Department of Pathology, University of North Carolina School of Medicine, North Carolina 27516, USA.
Abstract:
Causative molecular mechanisms accounting for the potential link between Chlamydia pneumoniae and atherosclerosis are unknown. Formalin and heat-inactivated C. pneumoniae activated the transcription factor nuclear factor (NF)-kappaB in cultured porcine endothelium and up-regulated the expression of E-selectin messenger RNA and protein. This up-regulation was abolished by an IkappaB super-repressor, an NF-kappaB-specific inhibitor. Live bacteria are not necessary for the activation of endothelial NF-kappaB, and C. pneumoniae may contribute to atherogenesis without active infection.
Related Concept Videos
NF-κB-dependent Signaling Pathway
NF-κB-dependent Signaling Mechanism
The heterodimer of NF-κB...
Bacterial Phylum Chlamydiae

