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Safety and immunogenicity of DNA/modified vaccinia virus ankara malaria vaccination in African adults

Vasee S Moorthy¹, Margaret Pinder, William H H Reece

¹Medical Research Council Laboratories, Banjul, The Gambia.

The Journal of Infectious Diseases

|October 11, 2003

Abstract:

The present study is an investigation of the safety and immunogenicity of DNA and modified vaccinia virus Ankara (MVA) candidate vaccines, each encoding the malaria DNA sequence multiple epitope-thrombospondin related adhesion protein (ME-TRAP), against Plasmodium falciparum. DNA ME-TRAP and MVA ME-TRAP are safe and immunogenic for effector and memory T cell induction. MVA ME-TRAP, with or without prior DNA ME-TRAP immunization, was more immunogenic and more cross-reactive in malaria-exposed individuals than in malaria-naive individuals, a finding suggesting that recombinant MVA vaccines are particularly promising for the development of a malaria vaccine for exposed populations. Both CD4(+) and CD8(+) T cells were induced by these vaccines.

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