Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Endothelial cell proliferation stimulated by basic fibroblast growth factor].

Wei-li Lu1, Yu-lan Dong

  • 1Laboratory of Experimental Pathology, China Medical University, Shenyang, Liaoning, P. R. China 110001.

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi = Zhongguo Xiufu Chongjian Waike Zazhi = Chinese Journal of Reparative and Reconstructive Surgery
|October 14, 2003
PubMed
Summary

Basic fibroblast growth factor (bFGF) stimulates endothelial cell (EC) proliferation by activating nuclear factor-kappa B (NF-kappa B). TNP-470 and dexamethasone inhibit this bFGF-induced EC proliferation by suppressing NF-kappa B.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Hepatocyte-specific Selenoi deficiency predisposes mice to hepatic steatosis and obesity.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2024
Same author

Mitochondrial stress induces hepatic stellate cell activation in response to the ATF4/TRIB3 pathway stimulation.

Journal of gastroenterology·2023
Same author

Risk model and factors for prediction of response to neoadjuvant chemotherapy in patients with advanced gastric cancer-a two-center cohort study.

BMC cancer·2023
Same author

CaM/CaMKII mediates activation and proliferation of hepatic stellate cells regulated by ASIC1a.

Frontiers in pharmacology·2023
Same author

Dietary Selenium Regulates microRNAs in Metabolic Disease: Recent Progress.

Nutrients·2021
Same author

Antitumor Effects of Extract of the Oak Bracket Medicinal Mushroom, Phellinus baumii (Agaricomycetes), on Human Melanoma Cells A375 In Vitro and In Vivo.

International journal of medicinal mushrooms·2020

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Biochemistry

Context:

  • Endothelial cells (ECs) play a crucial role in angiogenesis and vascular homeostasis.
  • Basic fibroblast growth factor (bFGF) is a potent stimulator of EC proliferation.
  • Understanding the molecular mechanisms underlying EC proliferation is vital for developing therapeutic strategies.

Purpose:

  • To investigate the effect of bFGF on EC proliferation in vitro.
  • To elucidate the signaling pathways involved in bFGF-induced EC proliferation, focusing on nuclear factor-kappa B (NF-kappa B).
  • To evaluate the inhibitory effects of TNP-470 and dexamethasone (Dex) on bFGF-mediated EC proliferation.

Summary:

  • bFGF significantly enhances EC proliferation and upregulates the expression of NF-kappa B and ki-67.

Related Experiment Videos

  • TNP-470 and Dex effectively suppress bFGF-induced EC proliferation.
  • These inhibitory effects are associated with reduced nuclear expression of NF-kappa B and ki-67.

    • Impact:

    • bFGF-induced EC proliferation is mediated through the activation of NF-kappa B, promoting DNA synthesis and mitosis.
    • TNP-470 and Dex exert their inhibitory effects by blocking the NF-kappa B signaling pathway.
    • These findings provide insights into the regulation of endothelial cell growth and potential therapeutic targets.