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Solid-phase synthesis: a paradigm shift.

Garland R Marshall1

  • 1Department of Biochemistry and Molecular Biophysics, Washington University Medical School, 700 S. Euclid Avenue, St Louis, MO 63110, USA. garland@pcg.wustl.edu

Journal of Peptide Science : an Official Publication of the European Peptide Society
|October 14, 2003
PubMed
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Solid-phase synthesis, pioneered by Professor R. Bruce Merrifield, revolutionized chemistry. This review details its evolution and widespread adoption across diverse chemical fields.

Area of Science:

  • Organic chemistry
  • Polymer chemistry
  • Medicinal chemistry

Background:

  • Professor R. Bruce Merrifield's pioneering work in solid-phase synthesis.
  • The personal perspective of his first graduate student.
  • Historical context of chemical synthesis methodologies.

Observation:

  • The evolution of solid-phase synthesis over time.
  • The varying acceptance of this technique by different chemistry sub-communities.
  • The initial challenges and eventual integration of solid-phase synthesis.

Findings:

  • Solid-phase synthesis has become a paradigm shift in chemistry.
  • The technique is now integral to biopolymer synthesis, combinatorial chemistry, and natural product synthesis.
  • Applications extend to catalyst selection, chemical ligation, and materials development.

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Implications:

  • Solid-phase synthesis significantly accelerates research and development in multiple chemical disciplines.
  • It enables the creation of complex molecules and novel materials.
  • The methodology continues to drive innovation in drug discovery and chemical biology.