Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Active hair bundle movements and the cochlear amplifier.

Anthony Ricci1

  • 1Neuroscience Center and Kresge Hearing Labs, Louisiana State Health Sciences Center, New Orleans 70112, USA. aricci@lsuhsc.edu

Journal of the American Academy of Audiology
|October 14, 2003
PubMed
Summary

The hearing organ's "active process" amplifies sound. Recent evidence suggests active hair bundle movements, alongside outer hair cell function, are crucial for hearing sensitivity and preventing hearing loss.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Weight cutting in female UFC fighters.

Journal of the International Society of Sports Nutrition·2023
Same author

Weight Loss and Competition Weight in Ultimate Fighting Championship (UFC) Athletes.

Journal of functional morphology and kinesiology·2022
Same author

<i>Loxhd1</i> Mutations Cause Mechanotransduction Defects in Cochlear Hair Cells.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2021
Same author

Homeostatic scaling of vesicular glutamate and GABA transporter expression in rat neocortical circuits.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2005
Same author

Electrophysiological characterization of C-terminal Kv4 channel fusion proteins.

Pflugers Archiv : European journal of physiology·2005
Same author

Molecules and mechanisms of mechanotransduction.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2004

Area of Science:

  • Auditory Neuroscience
  • Bioacoustics
  • Cellular Physiology

Background:

  • The
  • active process
  • in hearing organs provides exquisite sensitivity through amplification and filtering.
  • Dysfunction of the cochlear amplifier is linked to hearing impairments like threshold shifts, tinnitus, and sensorineural hearing loss.
  • Traditionally, outer hair cell (OHC) electromotility was considered the primary driver of the cochlear amplifier.

Purpose of the Study:

  • To review recent evidence on the components of the cochlear active process.
  • To explore the role of active hair bundle properties in auditory function.
  • To integrate the contributions of somatic motility and hair bundle activity to the cochlear active process.

Main Methods:

Related Experiment Videos

  • Literature review of recent research on cochlear active processes.
  • Analysis of evidence for active properties within the hair bundle.
  • Examination of gating compliance and adaptation mechanisms in hair cells.

Main Results:

  • Emerging evidence indicates that active properties of the hair bundle play a significant role in the cochlear amplifier.
  • Both outer hair cell somatic motility and active hair bundle movements likely contribute to the cochlear active process.
  • Active processes in hair bundle gating compliance, fast, and slow adaptation are key areas of investigation.

Conclusions:

  • The cochlear active process is likely a composite of outer hair cell electromotility and active hair bundle mechanics.
  • Understanding these active mechanisms is vital for comprehending normal hearing physiology.
  • Further research into hair bundle active properties may reveal new therapeutic targets for hearing disorders.