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[Relationship between aberrant FHIT transcripts and hepatocellular carcinoma]
Yong-chun Yu1, Fen-yong Sun, Zhi Li
1Center Laboratory, Railway Hospital Affiliated to Tongji University, Shanghai 200072, China.
Objective:
To study the relationship between aberrant FHIT transcripts and hepatocellular carcinoma (HCC).
Methods:
Reverse transcription-polymerase chain reaction (RT-PCR) and single strand conformational polymorphism (SSCP) assays were used to analyze the transcripts and mutations of FHIT gene in 24 matched tumorous tissues and para-tumorous tissues from patients with HCC and in 4 normal liver tissues.
Results:
Aberrant FHIT transcripts were observed in 11 out of 24 (46%) tumorous tissues and in 2 (8%) of the matched para-tumorous tissues.
Conclusion:
FHIT aberrant transcripts may play an important role in the pathogenesis of hepatocellular carcinoma.
