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Updated: Aug 11, 2026

Determination of the Relative Potency of an Anti-TNF Monoclonal Antibody (mAb) by Neutralizing TNF Using an In Vitro Bioanalytical Method
Published on: September 16, 2017
Novel chromene derivatives as TNF-alpha inhibitors
Jie-Fei Cheng1, Akira Ishikawa, Yoshinori Ono
1Department of Chemistry, Chugai Pharma USA, 6275 Nancy Ridge Drive, San Diego, CA 92121, USA. jcheng@chungai-pharm.com
Abstract:
A novel series of chromene-based TNF-alpha inhibitors is described. These chromene derivatives inhibit bacterial lipopolysaccharide (LPS) stimulated production of TNF-alpha from human peripheral blood mononuclear cells (PBMC). Additionally, these compounds inhibit NF-kB mediated transcription activation.
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